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| カタログ番号 | HX907014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PLCB3 Polyclonal Antibody (HX907014) is a rabbit polyclonal antibody detecting PLCB3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PLCB3 (Asp318-Lys468). | ||||||||
| ターゲット | Phospholipase C-beta-3, PLC-beta-3, 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, PLCB3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q01970 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3) is a ~138 kDa protein. Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. 1. Waldo, GL. et al. (2010) Science (New York, N.Y.) 330, 974-80. PMID: 20966218 2. Ben-Salem, S. et al. (2018) Journal of medical genetics 55, 122-130. PMID: 29122926 3. Falzone, ME. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2315011120. PMID: 37991948 4. Tall, E. et al. (1997) Biochemistry 36, 7239-48. PMID: 9188725 | ||||||||
| 注意事項 | For research use only. |
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