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| カタログ番号 | HT163014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PLK4 Polyclonal Antibody (HT163014) is a rabbit polyclonal antibody detecting PLK4 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Pongo abelii, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PLK4 (Met1-Pro263). | ||||||||
| ターゲット | PLK-4, Serine/threonine-protein kinase Sak, Serine/threonine-protein kinase PLK4, STK18, PLK4, Polo-like kinase 4, Serine/threonine-protein kinase 18, SAK | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00444 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein kinase PLK4 is a ~108 kDa protein. Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. 1. Tang, CJ. et al. (2011) The EMBO journal 30, 4790-804. PMID: 22020124 2. Denu, RA. et al. (2019) The Journal of biological chemistry 294, 6531-6549. PMID: 30804208 | ||||||||
| 注意事項 | For research use only. |
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