Anti-PLSCR1 Polyclonal Antibody (HT453014)

Name: Anti-PLSCR1 Polyclonal Antibody
Brand: abinScience
SKU: HT453014
Price: 96 USD
Availability: InStock

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SDS

Vista general

Número de catálogo

HT453014

Descripción

Anti-PLSCR1 Polyclonal Antibody (HT453014) is a rabbit polyclonal antibody detecting PLSCR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human PLSCR1 (Met1-Trp318).

Objetivo

Mg(2+)-dependent nuclease, Erythrocyte phospholipid scramblase, PLSCR1, PL scramblase 1, Phospholipid scramblase 1, MmTRA1b, Ca(2+)-dependent phospholipid scramblase 1

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O15162

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Phospholipid scramblase 1 (PLSCR1) is a ~35 kDa protein. Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation.

1. Frasch, SC. et al. (2000) The Journal of biological chemistry 275, 23065-73. PMID: 10770950

2. Sahu, SK. et al. (2008) Biotechnology letters 30, 2131-7. PMID: 18629440

3. Francis, VG. et al. (2013) The FEBS journal 280, 2855-69. PMID: 23590222

4. Shettihalli, AK. et al. (2013) Chemical research in toxicology 26, 918-25. PMID: 23659204

5. Sánchez-Magraner, L. et al. (2014) The Journal of membrane biology 247, 155-65. PMID: 24343571

6. Rayala, S. et al. (2014) The Journal of biological chemistry 289, 13206-18. PMID: 24648509

7. Ahyayauch, H. et al. (2018) Scientific reports 8, 7456. PMID: 29748552

8. Guo, J. et al. (2020) Cells 9. PMID: 32110987

9. Bassé, F. et al. (1996) The Journal of biological chemistry 271, 17205-10. PMID: 8663431

10. Zhou, Q. et al. (1997) The Journal of biological chemistry 272, 18240-4. PMID: 9218461

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-PLSCR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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