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| カタログ番号 | HT453014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PLSCR1 Polyclonal Antibody (HT453014) is a rabbit polyclonal antibody detecting PLSCR1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PLSCR1 (Met1-Trp318). | ||||||||
| ターゲット | Mg(2+)-dependent nuclease, Erythrocyte phospholipid scramblase, PLSCR1, PL scramblase 1, Phospholipid scramblase 1, MmTRA1b, Ca(2+)-dependent phospholipid scramblase 1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15162 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid scramblase 1 (PLSCR1) is a ~35 kDa protein. Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation. 1. Frasch, SC. et al. (2000) The Journal of biological chemistry 275, 23065-73. PMID: 10770950 2. Sahu, SK. et al. (2008) Biotechnology letters 30, 2131-7. PMID: 18629440 3. Francis, VG. et al. (2013) The FEBS journal 280, 2855-69. PMID: 23590222 4. Shettihalli, AK. et al. (2013) Chemical research in toxicology 26, 918-25. PMID: 23659204 5. Sánchez-Magraner, L. et al. (2014) The Journal of membrane biology 247, 155-65. PMID: 24343571 6. Rayala, S. et al. (2014) The Journal of biological chemistry 289, 13206-18. PMID: 24648509 7. Ahyayauch, H. et al. (2018) Scientific reports 8, 7456. PMID: 29748552 8. Guo, J. et al. (2020) Cells 9. PMID: 32110987 9. Bassé, F. et al. (1996) The Journal of biological chemistry 271, 17205-10. PMID: 8663431 10. Zhou, Q. et al. (1997) The Journal of biological chemistry 272, 18240-4. PMID: 9218461 | ||||||||
| 注意事項 | For research use only. |
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