

| Каталожный номер | HA796014 | ||||||||
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| Описание |
Anti-POLA2 Polyclonal Antibody (HA796014) is a rabbit polyclonal antibody detecting DNA polymerase alpha subunit B; DNA polymerase alpha 70 kDa subunit; POLA2 in ELISA, IHC, WB. Suitable for Human, Bovine, Rat, and Mouse.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant human POLA2 (Lys212-Ile598). | ||||||||
| Цель | DNA polymerase alpha subunit B; DNA polymerase alpha 70 kDa subunit; POLA2 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q14181, Q58D13, O89043, P33611 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | DNA polymerase alpha subunit B (POLA2) is a ~65 kDa protein. Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. 1. Schneider, A. et al. (1998) The Journal of biological chemistry 273, 21608-15. PMID: 9705292 | ||||||||
| Примечание | For research use only |
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