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| カタログ番号 | HC519014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PPP3CA (Ile7-Ser301). | ||||||||
| ターゲット | CAM-PRP catalytic subunit, CNA, Calmodulin-dependent calcineurin A subunit alpha isoform, CALNA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, PPP3CA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q08209 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein phosphatase 3 catalytic subunit alpha (PPP3CA) is a ~58 kDa protein. Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. 1. Wang, Y. et al. (2005) The Journal of biological chemistry 280, 12683-9. PMID: 15671020 2. Cereghetti, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15803-8. PMID: 18838687 3. Kilka, S. et al. (2009) Biochemistry 48, 1900-10. PMID: 19154138 4. Grigoriu, S. et al. (2013) PLoS biology 11, e1001492. PMID: 23468591 5. Rydzanicz, M. et al. (2019) European journal of human genetics : EJHG 27, 61-69. PMID: 30254215 6. Li, H. et al. (2007) Journal of molecular biology 369, 1296-306. PMID: 17498738 7. Takeuchi, K. et al. (2007) Structure (London, England : 1993) 15, 587-97. PMID: 17502104 8. Li, H. et al. (2012) Nature structural & molecular biology 19, 337-45. PMID: 22343722 9. Sheftic, SR. et al. (2016) Scientific reports 6, 38920. PMID: 27974827 | ||||||||
| 注意事項 | For research use only. |
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