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Anti-PQBP1 Polyclonal Antibody (HF653014)

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Aperçu
Numéro de catalogueHF653014
Description
Anti-PQBP1 Polyclonal Antibody (HF653014) is a rabbit polyclonal antibody detecting PQBP1 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Pongo pygmaeus, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human PQBP1 (Met1-Asp265).
Cible NPW38, PQBP1, Polyglutamine tract-binding protein 1, PQBP-1, Npw38, 38 kDa nuclear protein containing a WW domain, Polyglutamine-binding protein 1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O60828
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Polyglutamine-binding protein 1 (PQBP1) is a ~30 kDa protein. Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death.

1. Komuro, A. et al. (1999) Nucleic acids research 27, 1957-65. PMID: 10198427
2. Waragai, M. et al. (1999) Human molecular genetics 8, 977-87. PMID: 10332029
3. Okazawa, H. et al. (2002) Neuron 34, 701-13. PMID: 12062018
4. Tapia, VE. et al. (2010) The Journal of biological chemistry 285, 19391-401. PMID: 20410308
5. Wang, Q. et al. (2013) Genes & development 27, 615-26. PMID: 23512658
Note For research use only.
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Reférences
Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PQBP1 Polyclonal Antibody

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