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| カタログ番号 | HF522014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PRDM1 Polyclonal Antibody (HF522014) is a rabbit polyclonal antibody detecting PRDM1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PRDM1 (His493-Lys678). | ||||||||
| ターゲット | BLIMP-1, PRDI-BF1, PRDI-binding factor 1, BLIMP1, Positive regulatory domain I-binding factor 1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, PR domain zinc finger protein 1, PRDM1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75626 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | PR domain zinc finger protein 1 (PRDM1) is a ~91 kDa protein. Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. 1. Keller, AD. et al. (1991) Genes & development 5, 868-79. PMID: 1851123 2. Györy, I. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 3125-33. PMID: 12626569 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-PRDM1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A549 cell lysate
Lane 3: A431 cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: Raji cell lysate
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