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| カタログ番号 | HC365014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PRKAA1/AMPK alpha 1 Polyclonal Antibody (HC365014) is a rabbit polyclonal antibody detecting AMPK subunit alpha-1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PRKAA1/AMPK alpha 1 (Met10-Gln559). | ||||||||
| ターゲット | AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, Tau-protein kinase PRKAA1, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK1, PRKAA1, HMGCR kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13131 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1/AMPK alpha 1) is a ~64 kDa protein. Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2). 1. Towler, MC. et al. (2007) Circulation research 100, 328-41. PMID: 17307971 2. Hardie, DG. (2007) Nature reviews. Molecular cell biology 8, 774-85. PMID: 17712357 3. Bullen, JW. et al. (2014) The Journal of biological chemistry 289, 10592-10606. PMID: 24563466 4. Yang, JS. et al. (2019) Nature communications 10, 4068. PMID: 31492851 5. Wu, N. et al. (2023) Virology journal 20, 231. PMID: 37821951 6. Yang, JS. et al. (2025) Cell 188, 2569-2585.e20. PMID: 40233740 7. Liu, R. et al. (2021) Molecular cell 81, 2722-2735.e9. PMID: 34077757 8. Yang, W. et al. (2001) The Journal of biological chemistry 276, 38341-4. PMID: 11518699 | ||||||||
| 注意事項 | For research use only. |
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