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| カタログ番号 | HX978014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PRKAA2 Polyclonal Antibody (HX978014) is a rabbit polyclonal antibody detecting PRKAA2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Pongo abelii, and Pig.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PRKAA2 (Met1-Arg552). | ||||||||
| ターゲット | PRKAA2, Acetyl-CoA carboxylase kinase, AMPK subunit alpha-2, ACACA kinase, AMPK, AMPK2, Hydroxymethylglutaryl-CoA reductase kinase, 5'-AMP-activated protein kinase catalytic subunit alpha-2, HMGCR kinase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P54646 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) is a ~62 kDa protein. Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2). 1. Towler, MC. et al. (2007) Circulation research 100, 328-41. PMID: 17307971 2. Hardie, DG. (2007) Nature reviews. Molecular cell biology 8, 774-85. PMID: 17712357 3. Aguan, K. et al. (1994) Gene 149, 345-50. PMID: 7959015 4. Liu, R. et al. (2021) Molecular cell 81, 2722-2735.e9. PMID: 34077757 5. Boutchueng-Djidjou, M. et al. (2015) Molecular & cellular proteomics : MCP 14, 1079-92. PMID: 25687571 6. Yang, W. et al. (2001) The Journal of biological chemistry 276, 38341-4. PMID: 11518699 | ||||||||
| 注意事項 | For research use only. |
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