

| Numéro de catalogue | JN076034 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Pseudomonas aeruginosa impA Polyclonal Antibody (JN076034) is a rabbit polyclonal antibody detecting IMPa. Suitable for Pseudomonas aeruginosa.
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| Reactivité des espèces | Pseudomonas aeruginosa | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Pseudomonas aeruginosa impA (Ala42-Pro923). | ||||||||
| Cible | EC:3.4.24.-, IMPa, Immunomodulating metalloprotease, impA | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9I5W4 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Immunomodulating metalloprotease (impA) is a ~100 kDa protein. Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31. | ||||||||
| Note | For research use only |
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