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| カタログ番号 | HB835014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PTBP1 Polyclonal Antibody (HB835014) is a rabbit polyclonal antibody detecting PTBP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, Rat, and Pig.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PTBP1 (Met1-Ile531). | ||||||||
| ターゲット | PTB, Polypyrimidine tract-binding protein 1, 57 kDa RNA-binding protein PPTB-1, PTBP1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26599 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Polypyrimidine tract-binding protein 1 (PTBP1) is a ~59 kDa protein. Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. 1. Wang, J. et al. (2004) Journal of neurochemistry 88, 1078-90. PMID: 15009664 2. Zuccato, E. et al. (2004) The Journal of biological chemistry 279, 16980-8. PMID: 14966131 3. David, CJ. et al. (2010) Nature 463, 364-8. PMID: 20010808 4. Kafasla, P. et al. (2011) RNA (New York, N.Y.) 17, 1120-31. PMID: 21518806 | ||||||||
| 注意事項 | For research use only. |
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