

| Numéro de catalogue | HC629014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-PTK6 Polyclonal Antibody (HC629014) is a rabbit polyclonal antibody detecting PTK6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human PTK6 (Phe191-Thr445). | ||||||||
| Cible | Protein-tyrosine kinase 6, BRK, PTK6, Breast tumor kinase, Tyrosine-protein kinase BRK | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q13882 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Protein-tyrosine kinase 6 (PTK6) is a ~51 kDa protein. Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation. 1. Kang, SA. et al. (2010) The Journal of biological chemistry 285, 26013-21. PMID: 20554524 | ||||||||
| Note | For research use only. |
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