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Anti-PTPN11 Polyclonal Antibody (HC400014)

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Aperçu
Numéro de catalogueHC400014
Description
Anti-PTPN11 Polyclonal Antibody (HC400014) is a rabbit polyclonal antibody detecting PTPN11 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Chicken.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human PTPN11 (Met1-Arg593).
Cible Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-2C, Shp2, SHP-2, SH-PTP3, Protein-tyrosine phosphatase 2C, PTP2C, PTP-1D, PTPN11, SHPTP2, SH-PTP2
Purification Purified by antigen affinity column.
Numéro d'accès Q06124
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) is a ~68 kDa protein. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73.

1. Miao, H. et al. (2000) Nature cell biology 2, 62-9. PMID: 10655584
2. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280
3. Lee, HH. et al. (2008) The Journal of cell biology 181, 999-1012. PMID: 18559669
4. Jakob, S. et al. (2008) The Journal of biological chemistry 283, 33155-61. PMID: 18829466
5. Noda, S. et al. (2016) Biochemical and biophysical research communications 469, 1133-9. PMID: 26742426
6. Pannone, L. et al. (2017) Human mutation 38, 451-459. PMID: 28074573
7. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-PTPN11 Polyclonal Antibody

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