Anti-PTPN11 Polyclonal Antibody (HC400014)

Name: Anti-PTPN11 Polyclonal Antibody
Brand: abinScience
SKU: HC400014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HC400014

説明

Anti-PTPN11 Polyclonal Antibody (HC400014) is a rabbit polyclonal antibody detecting PTPN11 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human PTPN11 (Met1-Arg593).

ターゲット

Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-2C, Shp2, SHP-2, SH-PTP3, Protein-tyrosine phosphatase 2C, PTP2C, PTP-1D, PTPN11, SHPTP2, SH-PTP2

精製

Purified by antigen affinity column.

アクセッション番号

Q06124

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) is a ~68 kDa protein. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73.

1. Miao, H. et al. (2000) Nature cell biology 2, 62-9. PMID: 10655584

2. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

3. Lee, HH. et al. (2008) The Journal of cell biology 181, 999-1012. PMID: 18559669

4. Jakob, S. et al. (2008) The Journal of biological chemistry 283, 33155-61. PMID: 18829466

5. Noda, S. et al. (2016) Biochemical and biophysical research communications 469, 1133-9. PMID: 26742426

6. Pannone, L. et al. (2017) Human mutation 38, 451-459. PMID: 28074573

7. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-PTPN11 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-PTPN11 Polyclonal Antibody (HC400014)

概要

イメージ

参考文献

データシート

SDS