

| Número de catálogo | HB969014 | ||||||||
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| Descripción |
Anti-PTPN2 Polyclonal Antibody (HB969014) is a rabbit polyclonal antibody detecting PTPN2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human PTPN2 (Met1-Gly257). | ||||||||
| Objetivo | Tyrosine-protein phosphatase non-receptor type 2, TCPTP, T-cell protein-tyrosine phosphatase, PTPT, PTPN2 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P17706 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) is a ~48 kDa protein. Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. | ||||||||
| Nota | For research use only. |
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