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Anti-PTPN4 Polyclonal Antibody (HA691014)

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Aperçu
Numéro de catalogueHA691014
Description
Anti-PTPN4 Polyclonal Antibody (HA691014) is a rabbit polyclonal antibody detecting Tyrosine-protein phosphatase non-receptor type 4; 3.1.3.48; Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1; PTPN4 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant human PTPN4 (Asp636-Lys926).
Cible Tyrosine-protein phosphatase non-receptor type 4; 3.1.3.48; Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1; PTPN4
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P29074, Q9WU22
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) is a ~105 kDa protein. Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.

1. Huai, W. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 4458-65. PMID: 25825441
2. Maisonneuve, P. et al. (2016) The Journal of biological chemistry 291, 16699-708. PMID: 27246854
3. Préhaud, C. et al. (2010) Science signaling 3, ra5. PMID: 20086240
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PTPN4 Polyclonal Antibody

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