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| カタログ番号 | HB806014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PTPN6 Polyclonal Antibody (HB806014) is a rabbit polyclonal antibody detecting PTPN6 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PTPN6 (Phe244-Phe515). | ||||||||
| ターゲット | HCP, PTPN6, PTP1C, Hematopoietic cell protein-tyrosine phosphatase, SH-PTP1, Protein-tyrosine phosphatase SHP-1, Protein-tyrosine phosphatase 1C, Tyrosine-protein phosphatase non-receptor type 6, PTP-1C | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P29350 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) is a ~67 kDa protein. Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling. 1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280 2. Aki, D. et al. (2018) Nature immunology 19, 766-775. PMID: 29925997 3. Hsu, JM. et al. (2011) Nature cell biology 13, 174-81. PMID: 21258366 4. Keilhack, H. et al. (1998) The Journal of biological chemistry 273, 24839-46. PMID: 9733788 5. Bellón, T. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 3351-9. PMID: 11907092 6. Velasco Cárdenas, RM. et al. (2023) Nature immunology 24, 2135-2149. PMID: 37932456 7. Poirier, A. et al. (2024) Science signaling 17, eadg4422. PMID: 38166031 8. Imani, F. et al. (1997) The Journal of biological chemistry 272, 7927-31. PMID: 9065461 9. Wang, Y. et al. (2022) Cellular & molecular immunology 19, 108-121. PMID: 34811497 10. Chyuan, IT. et al. (2024) Journal of biomedical science 31, 33. PMID: 38532423 | ||||||||
| 注意事項 | For research use only. |
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