

| Numéro de catalogue | HB279014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-PTPRB Polyclonal Antibody (HB279014) is a rabbit polyclonal antibody detecting PTPRB in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human PTPRB (Ala1655-Asp1918). | ||||||||
| Cible | R-PTP-beta, Receptor-type tyrosine-protein phosphatase beta, PTPB, Vascular endothelial protein tyrosine phosphatase, VE-PTP, Protein-tyrosine phosphatase beta, PTPRB | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P23467 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Receptor-type tyrosine-protein phosphatase beta (PTPRB) is a ~224 kDa protein. Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. | ||||||||
| Note | For research use only. |
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