

| Numéro de catalogue | HB921014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-PTPRM Polyclonal Antibody (HB921014) is a rabbit polyclonal antibody detecting PTPRM in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human PTPRM (Thr1197-Ser1403). | ||||||||
| Cible | Protein-tyrosine phosphatase mu, R-PTP-mu, PTPRL1, PTPRM, Receptor-type tyrosine-protein phosphatase mu | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P28827 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Receptor-type tyrosine-protein phosphatase mu (PTPRM) is a ~163 kDa protein. Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function. 1. Zondag, GC. et al. (2000) The Journal of biological chemistry 275, 11264-9. PMID: 10753936 2. Aricescu, AR. et al. (2007) Science (New York, N.Y.) 317, 1217-20. PMID: 17761881 3. Kim, WK. et al. (2011) Molecular biology of the cell 22, 4883-91. PMID: 21998202 | ||||||||
| Note | For research use only. |
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