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| カタログ番号 | HX207014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RAB1A Polyclonal Antibody (HX207014) is a rabbit polyclonal antibody detecting RAB1A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB1A (Met1-Cys205). | ||||||||
| ターゲット | Ras-related protein Rab-1A, YPT1-related protein, RAB1A, RAB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P62820 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-1A (RAB1A) is a ~22 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane. 1. Wang, C. et al. (2010) The Journal of biological chemistry 285, 29398-405. PMID: 20639577 2. Zhuang, X. et al. (2010) Endocrinology 151, 5114-23. PMID: 20861236 3. Mukhopadhyay, A. et al. (2011) Journal of cell science 124, 765-75. PMID: 21303926 4. Dong, N. et al. (2012) Cell 150, 1029-41. PMID: 22939626 5. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634 | ||||||||
| 注意事項 | For research use only. |
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