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| カタログ番号 | HW603014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RAB7A Polyclonal Antibody (HW603014) is a rabbit polyclonal antibody detecting RAB7A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB7A (Met1-Cys207). | ||||||||
| ターゲット | RAB7A, RAB7, Ras-related protein Rab-7a | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51149 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-7a (RAB7A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. 1. Li, L. et al. (2024) Nature 628, 630-638. PMID: 38538795 2. Cantalupo, G. et al. (2001) The EMBO journal 20, 683-93. PMID: 11179213 3. Harrison, RE. et al. (2003) Molecular and cellular biology 23, 6494-506. PMID: 12944476 4. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358 5. McCray, BA. et al. (2010) Human molecular genetics 19, 1033-47. PMID: 20028791 6. Seto, S. et al. (2011) Traffic (Copenhagen, Denmark) 12, 407-20. PMID: 21255211 7. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413 8. Daniloski, Z. et al. (2021) Cell 184, 92-105.e16. PMID: 33147445 | ||||||||
| 注意事項 | For research use only. |
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