Anti-RAB7A Polyclonal Antibody (HW603014)

Name: Anti-RAB7A Polyclonal Antibody
Brand: abinScience
SKU: HW603014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HW603014

Описание

Anti-RAB7A Polyclonal Antibody (HW603014) is a rabbit polyclonal antibody detecting RAB7A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RAB7A (Met1-Cys207).

Цель

RAB7A, RAB7, Ras-related protein Rab-7a

Очистка

Purified by antigen affinity column.

Номер доступа

P51149

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Ras-related protein Rab-7a (RAB7A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In its active state, RAB7A binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Also plays a central role in growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism.

1. Li, L. et al. (2024) Nature 628, 630-638. PMID: 38538795

2. Cantalupo, G. et al. (2001) The EMBO journal 20, 683-93. PMID: 11179213

3. Harrison, RE. et al. (2003) Molecular and cellular biology 23, 6494-506. PMID: 12944476

4. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358

5. McCray, BA. et al. (2010) Human molecular genetics 19, 1033-47. PMID: 20028791

6. Seto, S. et al. (2011) Traffic (Copenhagen, Denmark) 12, 407-20. PMID: 21255211

7. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

8. Daniloski, Z. et al. (2021) Cell 184, 92-105.e16. PMID: 33147445

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-RAB7A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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