

| Numéro de catalogue | HA549014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-RAD21 Polyclonal Antibody (HA549014) is a rabbit polyclonal antibody detecting RAD21 in WB, IHC, ELISA. Suitable for Human, Mus musculus, and Bovine.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | WB, IHC, ELISA | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant RAD21 (Glu147-Thr349). | ||||||||
| Cible | RAD21 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Pureté | >90% as determined by SDS-PAGE. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O60216 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Noms alternatifs | Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, 64-kDa C-terminal product, 64-kDa carboxy-terminal product, 65-kDa carboxy-terminal product, RAD21 | ||||||||
| Contexte | Double-strand-break repair protein rad21 homolog is a ~71 kDa protein. As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. 1. Hauf, S. et al. (2001) Science (New York, N.Y.) 293, 1320-3. PMID: 11509732 2. Gregson, HC. et al. (2001) The Journal of biological chemistry 276, 47575-82. PMID: 11590136 3. Bonora, E. et al. (2015) Gastroenterology 148, 771-782.e11. PMID: 25575569 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-RAD21 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
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