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| カタログ番号 | HA549014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RAD21 Polyclonal Antibody (HA549014) is a rabbit polyclonal antibody detecting RAD21 in WB, IHC, ELISA. Suitable for Human, Mus musculus, and Bovine.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | WB, IHC, ELISA | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant RAD21 (Glu147-Thr349). | ||||||||
| ターゲット | RAD21 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >90% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60216 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, 64-kDa C-terminal product, 64-kDa carboxy-terminal product, 65-kDa carboxy-terminal product, RAD21 | ||||||||
| 背景 | Double-strand-break repair protein rad21 homolog is a ~71 kDa protein. As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. 1. Hauf, S. et al. (2001) Science (New York, N.Y.) 293, 1320-3. PMID: 11509732 2. Gregson, HC. et al. (2001) The Journal of biological chemistry 276, 47575-82. PMID: 11590136 3. Bonora, E. et al. (2015) Gastroenterology 148, 771-782.e11. PMID: 25575569 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-RAD21 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
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