Anti-RARA Polyclonal Antibody (HY483014)

Name: Anti-RARA Polyclonal Antibody
Brand: abinScience
SKU: HY483014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HY483014

Description

Anti-RARA Polyclonal Antibody (HY483014) is a rabbit polyclonal antibody detecting RARA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Coturnix japonica, and Danio rerio.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human RARA (Ser68-Glu173).

Cible

RARA, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, RAR-alpha, NR1B1

Purification

Purified by antigen affinity column.

Numéro d'accès

P10276

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Retinoic acid receptor alpha (RARA) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation.

1. Srinivas, H. et al. (2006) The Biochemical journal 395, 653-62. PMID: 16417524

2. Zhu, L. et al. (2009) Endocrinology 150, 5586-95. PMID: 19850744

3. Santos, NC. et al. (2010) Endocrinology 151, 2361-72. PMID: 20215566

4. Sato, Y. et al. (2010) PloS one 5, e15119. PMID: 21152046

5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

6. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758

7. Qin, Z. et al. (2009) Molecular and cellular biology 29, 3633-43. PMID: 19398580

Note

For research use only.

Images

Reférences

Fiche technique

Anti-RARA Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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