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| カタログ番号 | HY483014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RARA Polyclonal Antibody (HY483014) is a rabbit polyclonal antibody detecting RARA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Coturnix japonica, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RARA (Ser68-Glu173). | ||||||||
| ターゲット | RARA, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, RAR-alpha, NR1B1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10276 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Retinoic acid receptor alpha (RARA) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. 1. Srinivas, H. et al. (2006) The Biochemical journal 395, 653-62. PMID: 16417524 2. Zhu, L. et al. (2009) Endocrinology 150, 5586-95. PMID: 19850744 3. Santos, NC. et al. (2010) Endocrinology 151, 2361-72. PMID: 20215566 4. Sato, Y. et al. (2010) PloS one 5, e15119. PMID: 21152046 5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 6. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758 7. Qin, Z. et al. (2009) Molecular and cellular biology 29, 3633-43. PMID: 19398580 | ||||||||
| 注意事項 | For research use only. |
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