Anti-Rat ARC Recombinant Nanobody (E5#) (RV329033)

Name: Anti-Rat ARC Recombinant Nanobody (E5#)
Brand: abinScience
SKU: RV329033
Price: 126 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

RV329033

Descripción

Anti-Rat ARC Nanobody (E5#) [E5#] (RV329033) is a alpaca monoclonal antibody detecting Arc in ELISA, Neutralization. Suitable for Rat.

Reactividad de especies

Rat

Aplicaciones

ELISA, Neutralization

Especie huésped

Alpaca

Clonalidad

Monoclonal

Isotipo

VHH-Avi-8His-Cys-tag

ID de clon

E5#

Objetivo

Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein, ARC/ARG3.1, Arg3.1, Arc

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by Nickel column.

Número de acceso

Q63053

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Activity-regulated cytoskeleton-associated protein (ARC) is a ~45 kDa protein. Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis.

1. Pastuzyn, ED. et al. (2018) Cell 172, 275-288.e18. PMID: 29328916

2. Guzowski, JF. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 3993-4001. PMID: 10818134

3. Chowdhury, S. et al. (2006) Neuron 52, 445-59. PMID: 17088211

4. Rial Verde, EM. et al. (2006) Neuron 52, 461-74. PMID: 17088212

5. Shepherd, JD. et al. (2006) Neuron 52, 475-84. PMID: 17088213

6. Mikuni, T. et al. (2013) Neuron 78, 1024-35. PMID: 23791196

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Rat ARC Nanobody (E5#)

Referencias

Datasheet

Anti-Rat ARC Recombinant Nanobody (E5#).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo