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| カタログ番号 | RV329023 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-Rat ARC Nanobody (SAA1467) [SAA1467] (RV329023) is a alpaca monoclonal antibody detecting ARC in ELISA, Neutralization. Suitable for Rat.
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| 種反応性 | Rat | ||||
| アプリケーション | ELISA, Neutralization | ||||
| 宿主種 | Alpaca | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-Avi-8His-Cys-tag | ||||
| クローンID | SAA1467 | ||||
| ターゲット | ARC, KIAA0278, Activity-regulated cytoskeleton-associated protein, ARC/ARG3.1, Activity-regulated gene 3.1 protein homolog, hArc, Arg3.1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by Nickel column | ||||
| アクセッション番号 | Q63053 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Activity-regulated cytoskeleton-associated protein (ARC) is a ~45 kDa protein. Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. 1. Pastuzyn, ED. et al. (2018) Cell 172, 275-288.e18. PMID: 29328916 2. Guzowski, JF. et al. (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20, 3993-4001. PMID: 10818134 3. Chowdhury, S. et al. (2006) Neuron 52, 445-59. PMID: 17088211 4. Rial Verde, EM. et al. (2006) Neuron 52, 461-74. PMID: 17088212 5. Shepherd, JD. et al. (2006) Neuron 52, 475-84. PMID: 17088213 6. Mikuni, T. et al. (2013) Neuron 78, 1024-35. PMID: 23791196 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Rat ARC Nanobody (SAA1467)
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