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Anti-Rat DIO1 Polyclonal Antibody (RW476014)

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Vista general
Número de catálogoRW476014
Descripción
Anti-Rat DIO1 Polyclonal Antibody (RW476014) is a rabbit polyclonal antibody detecting DIO1. Suitable for Rat and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesMouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Rat DIO1 (Arg85-Phe257).
Objetivo 5DI, DIO1, DIOI, EC:1.21.99.3, EC:1.21.99.4, ITDI1, TXDI1, Type 1 DI, Type I iodothyronine deiodinase, Type-I 5'-deiodinase
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P24389
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Type I iodothyronine deiodinase (DIO1) is a ~29 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine.

1. Berry, MJ. (1992) The Journal of biological chemistry 267, 18055-9. PMID: 1517238
2. Leonard, JL. et al. (1991) The Journal of biological chemistry 266, 11262-9. PMID: 2040632
3. Toyoda, N. et al. (1995) The Journal of biological chemistry 270, 12310-8. PMID: 7744884
4. Berry, MJ. et al. (1991) Nature 349, 438-40. PMID: 1825132
5. Moreno, M. et al. (1994) FEBS letters 344, 143-6. PMID: 8187873
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Rat DIO1 Polyclonal Antibody

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