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| カタログ番号 | RW476014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Rat DIO1 Polyclonal Antibody (RW476014) is a rabbit polyclonal antibody detecting DIO1. Suitable for Rat and Mouse.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Rat DIO1 (Arg85-Phe257). | ||||||||
| ターゲット | 5DI, DIO1, DIOI, EC:1.21.99.3, EC:1.21.99.4, ITDI1, TXDI1, Type 1 DI, Type I iodothyronine deiodinase, Type-I 5'-deiodinase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P24389 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Type I iodothyronine deiodinase (DIO1) is a ~29 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine. 1. Berry, MJ. (1992) The Journal of biological chemistry 267, 18055-9. PMID: 1517238 2. Leonard, JL. et al. (1991) The Journal of biological chemistry 266, 11262-9. PMID: 2040632 3. Toyoda, N. et al. (1995) The Journal of biological chemistry 270, 12310-8. PMID: 7744884 4. Berry, MJ. et al. (1991) Nature 349, 438-40. PMID: 1825132 5. Moreno, M. et al. (1994) FEBS letters 344, 143-6. PMID: 8187873 | ||||||||
| 注意事項 | For research use only |
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