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| カタログ番号 | HY189014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RB1 Polyclonal Antibody (HY189014) is a rabbit polyclonal antibody detecting RB1 in ELISA, IHC, WB. Suitable for Mouse, Human, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RB1 (Gln639-Thr778). | ||||||||
| ターゲット | pRb, p110-RB1, Retinoblastoma-associated protein, Rb, p105-Rb, RB1, pp110 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P06400 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Retinoblastoma-associated protein (RB1) is a ~106 kDa protein. Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. 1. Harbour, JW. et al. (1999) Cell 98, 859-69. PMID: 10499802 2. Ren, S. et al. (2004) Cell 117, 239-51. PMID: 15084261 | ||||||||
| 注意事項 | For research use only. |
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