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| カタログ番号 | HB545014 | ||||||||
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| 説明 |
Anti-RBM33 Polyclonal Antibody (HB545014) is a rabbit polyclonal antibody detecting RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33; RBM33; PRR8 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human RBM33 (Gln1096-Glu1170). | ||||||||
| ターゲット | RNA-binding protein 33; Proline-rich protein 8; RNA-binding motif protein 33; RBM33; PRR8 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96EV2, Q9CXK9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RNA-binding protein 33 (RBM33) is a ~129 kDa protein. RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation. 1. Thomas, A. et al. (2022) Genes & development 36, 550-565. PMID: 35589130 2. Yu, F. et al. (2023) Molecular cell 83, 2003-2019.e6. PMID: 37257451 | ||||||||
| 注意事項 | For research use only |
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