Anti-REXO2 Polyclonal Antibody (HV708014)

Name: Anti-REXO2 Polyclonal Antibody
Brand: abinScience
SKU: HV708014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV708014

Description

Anti-REXO2 Polyclonal Antibody (HV708014) is a rabbit polyclonal antibody detecting REXO2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human REXO2 (Gln41-Asn213).

Cible

Small fragment nuclease, SMFN, REXO2, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, SFN

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y3B8

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Oligoribonuclease, mitochondrial (REXO2) is a ~26 kDa protein. 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.

1. Bruni, F. et al. (2013) PloS one 8, e64670. PMID: 23741365

2. Chu, LY. et al. (2019) RNA (New York, N.Y.) 25, 737-746. PMID: 30926754

3. Nicholls, TJ. et al. (2019) Molecular cell 76, 784-796.e6. PMID: 31588022

4. Szewczyk, M. et al. (2020) Nucleic acids research 48, 5572-5590. PMID: 32365187

Note

For research use only.

Images

Reférences

Fiche technique

Anti-REXO2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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