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| カタログ番号 | HV708014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-REXO2 Polyclonal Antibody (HV708014) is a rabbit polyclonal antibody detecting REXO2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human REXO2 (Gln41-Asn213). | ||||||||
| ターゲット | Small fragment nuclease, SMFN, REXO2, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, SFN | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y3B8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Oligoribonuclease, mitochondrial (REXO2) is a ~26 kDa protein. 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. 1. Bruni, F. et al. (2013) PloS one 8, e64670. PMID: 23741365 2. Chu, LY. et al. (2019) RNA (New York, N.Y.) 25, 737-746. PMID: 30926754 3. Nicholls, TJ. et al. (2019) Molecular cell 76, 784-796.e6. PMID: 31588022 4. Szewczyk, M. et al. (2020) Nucleic acids research 48, 5572-5590. PMID: 32365187 | ||||||||
| 注意事項 | For research use only. |
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