

| Número de catálogo | HV431014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-RNF112 Polyclonal Antibody (HV431014) is a rabbit polyclonal antibody detecting RNF112 in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
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| Reactividad de especies | Human, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human RNF112 (Gly73-His322). | ||||||||
| Objetivo | BFP, RNF112, ZNF179, Brain finger protein, Zinc finger protein 179, RING finger protein 112 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9ULX5 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | RING finger protein 112 (RNF112) is a ~68 kDa protein. E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. 1. Lee, KH. et al. (2017) Scientific reports 7, 4787. PMID: 28684796 | ||||||||
| Nota | For research use only. |
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