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Anti-RNF113A Polyclonal Antibody (HB570014)

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Vista general
Número de catálogoHB570014
Descripción
Anti-RNF113A Polyclonal Antibody (HB570014) is a rabbit polyclonal antibody detecting E3 ubiquitin-protein ligase RNF113A; 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183; RNF113A; RNF113; ZNF183 in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human RNF113A (Ile201-Thr343).
Objetivo E3 ubiquitin-protein ligase RNF113A; 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183; RNF113A; RNF113; ZNF183
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O15541, Q67ER4
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

E3 ubiquitin-protein ligase RNF113A is a ~38 kDa protein. Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents.

1. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106
2. Haselbach, D. et al. (2018) Cell 172, 454-464.e11. PMID: 29361316
3. Lear, T. et al. (2017) American journal of physiology. Cell physiology 313, C584-C592. PMID: 28978524
4. Brickner, JR. et al. (2017) Nature 551, 389-393. PMID: 29144457
Nota For research use only
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