Anti-RNF126 Polyclonal Antibody (HC013014)

Name: Anti-RNF126 Polyclonal Antibody
Brand: abinScience
SKU: HC013014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HC013014

Description

Anti-RNF126 Polyclonal Antibody (HC013014) is a rabbit polyclonal antibody detecting RNF126 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant RNF126 (Met1-Ser311).

Cible

E3 ubiquitin-protein ligase RNF126, EC:2.3.2.27, RING finger protein 126, RNF126

Niveau d'endotoxines

Please contact with the lab for this information.

Masse moléculaire observée

~40 kDa

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9BV68, Q91YL2, Q0II22

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

E3 ubiquitin-protein ligase RNF126 is a ~33 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor.

1. Delker, RK. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 1029-34. PMID: 23277564

2. Smith, CJ. et al. (2014) Experimental cell research 320, 219-32. PMID: 24275455

3. Rodrigo-Brenni, MC. et al. (2014) Molecular cell 55, 227-37. PMID: 24981174

4. Liu, W. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2203884. PMID: 36563124

5. Mock, JY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 11679-11684. PMID: 29042515

6. Smith, CJ. et al. (2013) Journal of cell science 126, 1366-80. PMID: 23418353

7. Zhi, X. et al. (2013) Cancer research 73, 385-94. PMID: 23026136

Note

For research use only

Images

Reférences

Fiche technique

Anti-RNF126 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-RNF126 Polyclonal Antibody (HC013014)

Aperçu

Images

Reférences

Fiche technique

SDS