Anti-RNF126 Polyclonal Antibody (HC013014)

Name: Anti-RNF126 Polyclonal Antibody
Brand: abinScience
SKU: HC013014
Price: 168 USD
Availability: InStock

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100ug

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Каталожный номер

HC013014

Описание

Anti-RNF126 Polyclonal Antibody (HC013014) is a rabbit polyclonal antibody detecting RNF126 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant RNF126 (Met1-Ser311).

Цель

E3 ubiquitin-protein ligase RNF126, EC:2.3.2.27, RING finger protein 126, RNF126

Уровень эндотоксинов

Please contact with the lab for this information.

Наблюдаемая молекулярная масса

~40 kDa

Очистка

Purified by antigen affinity column.

Номер доступа

Q9BV68, Q91YL2, Q0II22

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

E3 ubiquitin-protein ligase RNF126 is a ~33 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor.

1. Delker, RK. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 1029-34. PMID: 23277564

2. Smith, CJ. et al. (2014) Experimental cell research 320, 219-32. PMID: 24275455

3. Rodrigo-Brenni, MC. et al. (2014) Molecular cell 55, 227-37. PMID: 24981174

4. Liu, W. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2203884. PMID: 36563124

5. Mock, JY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 11679-11684. PMID: 29042515

6. Smith, CJ. et al. (2013) Journal of cell science 126, 1366-80. PMID: 23418353

7. Zhi, X. et al. (2013) Cancer research 73, 385-94. PMID: 23026136

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-RNF126 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-RNF126 Polyclonal Antibody (HC013014)

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