Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014)

Name: Anti-RORC/NR1F3/RORgT Polyclonal Antibody
Brand: abinScience
SKU: HW351014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW351014

Descripción

Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014) is a rabbit polyclonal antibody detecting NR1F3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human RORC/NR1F3/RORgT (Glu212-Ser461).

Objetivo

RAR-related orphan receptor C, RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Retinoid-related orphan receptor-gamma, RZRG, Nuclear receptor subfamily 1 group F member 3, RORG, RORgT

Purificación

Purified by antigen affinity column.

Número de acceso

P51449

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Nuclear receptor ROR-gamma (RORC/NR1F3) is a ~58 kDa protein. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner.

1. Jetten, AM. (2009) Nuclear receptor signaling 7, e003. PMID: 19381306

2. Wang, Y. et al. (2010) The Journal of biological chemistry 285, 5013-25. PMID: 19965867

3. Jin, L. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 923-9. PMID: 20203100

4. Solt, LA. et al. (2012) Trends in endocrinology and metabolism: TEM 23, 619-27. PMID: 22789990

5. Okada, S. et al. (2015) Science (New York, N.Y.) 349, 606-613. PMID: 26160376

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-RORC/NR1F3/RORgT Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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