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| カタログ番号 | HW351014 | ||||||||
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| 説明 |
Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014) is a rabbit polyclonal antibody detecting NR1F3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RORC/NR1F3/RORgT (Glu212-Ser461). | ||||||||
| ターゲット | RAR-related orphan receptor C, RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Retinoid-related orphan receptor-gamma, RZRG, Nuclear receptor subfamily 1 group F member 3, RORG, RORgT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51449 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nuclear receptor ROR-gamma (RORC/NR1F3) is a ~58 kDa protein. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. 1. Jetten, AM. (2009) Nuclear receptor signaling 7, e003. PMID: 19381306 2. Wang, Y. et al. (2010) The Journal of biological chemistry 285, 5013-25. PMID: 19965867 3. Jin, L. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 923-9. PMID: 20203100 4. Solt, LA. et al. (2012) Trends in endocrinology and metabolism: TEM 23, 619-27. PMID: 22789990 5. Okada, S. et al. (2015) Science (New York, N.Y.) 349, 606-613. PMID: 26160376 | ||||||||
| 注意事項 | For research use only. |
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