Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014)

Name: Anti-RORC/NR1F3/RORgT Polyclonal Antibody
Brand: abinScience
SKU: HW351014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HW351014

Описание

Anti-RORC/NR1F3/RORgT Polyclonal Antibody (HW351014) is a rabbit polyclonal antibody detecting NR1F3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human RORC/NR1F3/RORgT (Glu212-Ser461).

Цель

RAR-related orphan receptor C, RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Retinoid-related orphan receptor-gamma, RZRG, Nuclear receptor subfamily 1 group F member 3, RORG, RORgT

Очистка

Purified by antigen affinity column.

Номер доступа

P51449

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Nuclear receptor ROR-gamma (RORC/NR1F3) is a ~58 kDa protein. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner.

1. Jetten, AM. (2009) Nuclear receptor signaling 7, e003. PMID: 19381306

2. Wang, Y. et al. (2010) The Journal of biological chemistry 285, 5013-25. PMID: 19965867

3. Jin, L. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 923-9. PMID: 20203100

4. Solt, LA. et al. (2012) Trends in endocrinology and metabolism: TEM 23, 619-27. PMID: 22789990

5. Okada, S. et al. (2015) Science (New York, N.Y.) 349, 606-613. PMID: 26160376

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-RORC/NR1F3/RORgT Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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