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Anti-RPA1 Polyclonal Antibody (HA686014)

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Anti-RPA1 Polyclonal Antibody
Anti-RPA1 Polyclonal Antibody
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Vista general
Número de catálogoHA686014
Descripción
Anti-RPA1 Polyclonal Antibody (HA686014) is a rabbit polyclonal antibody detecting N-terminally processed; RPA1; REPA1; RPA70 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human RPA1 (Ile187-Met616).
Objetivo Replication protein A 70 kDa DNA-binding subunit; RP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding protein; Replication protein A 70 kDa DNA-binding subunit, N-terminally processed; RPA1; REPA1; RPA70
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P27694, Q8VEE4
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Replication protein A 70 kDa DNA-binding subunit (RPA1) is a ~68 kDa protein. As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response.

1. Gupta, R. et al. (2007) Blood 110, 2390-8. PMID: 17596542
2. Haahr, P. et al. (2016) Nature cell biology 18, 1196-1207. PMID: 27723717
3. Bass, TE. et al. (2016) Nature cell biology 18, 1185-1195. PMID: 27723720
4. Lin, YL. et al. (1998) The Journal of biological chemistry 273, 1453-61. PMID: 9430682
5. Maréchal, A. et al. (2014) Molecular cell 53, 235-246. PMID: 24332808
6. Sleeth, KM. et al. (2007) Journal of molecular biology 373, 38-47. PMID: 17765923
7. Aboussekhra, A. et al. (1995) Cell 80, 859-68. PMID: 7697716
8. DeMott, MS. et al. (1998) The Journal of biological chemistry 273, 27492-8. PMID: 9765279
9. Grudic, A. et al. (2007) Nucleic acids research 35, 7267-78. PMID: 17959650
10. Sharma, R. et al. (2022) Blood 139, 1039-1051. PMID: 34767620
Nota For research use only
Imágenes
  • Anti-RPA1 Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-RPA1 polyclonal antibody at 1ug/mL on various samples.
    Lane 1: Lncap cell lysate

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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