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| カタログ番号 | HX866014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RUNX1/RUNX2/RUNX3 Polyclonal Antibody (HX866014) is a rabbit polyclonal antibody detecting RUNX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human RUNX1 (Met1-Tyr480). | ||||||||
| ターゲット | Isoform AML-1G of Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, RUNX1, AML1, CBFA2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q01196, Q63046, Q03347, Q6PF39, Q13950, Q9Z2J9, Q08775, Q13761, Q64131 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Runt-related transcription factor 1 is a ~48 kDa protein. Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. 1. Fujimoto, T. et al. (2007) The EMBO journal 26, 2361-70. PMID: 17431401 2. Mao, S. et al. (1999) Molecular and cellular biology 19, 3635-44. PMID: 10207087 3. Cho, JY. et al. (2004) The Journal of biological chemistry 279, 19512-22. PMID: 14970218 4. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 | ||||||||
| 注意事項 | For research use only |
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