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Anti-RUNX2 Polyclonal Antibody (HC637014)

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Vista general
Número de catálogoHC637014
Descripción
Anti-RUNX2 Polyclonal Antibody (HC637014) is a rabbit polyclonal antibody detecting RUNX2 in ELISA, IHC, WB. Suitable for Rat, Human, and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human RUNX2 (Val219-Val404).
Objetivo AML3, OSF2, RUNX2, Core-binding factor subunit alpha-1, PEA2-alpha A, CBF-alpha-1, Osteoblast-specific transcription factor 2, Oncogene AML-3, CBFA1, Runt-related transcription factor 2, PEBP2A, OSF-2, SL3-3 enhancer factor 1 alpha A subunit, PEBP2-alpha A, Acute myeloid leukemia 3 protein, Polyomavirus enhancer-binding protein 2 alpha A subunit, SL3/AKV core-binding factor alpha A subunit
Purificación Purified by antigen affinity column.
Número de acceso Q13950
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Runt-related transcription factor 2 (RUNX2) is a ~56 kDa protein. Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.

1. Zeng, L. et al. (2017) Mutagenesis 32, 437-443. PMID: 28505335
2. Jung, YJ. et al. (2018) Journal of cellular biochemistry 119, 1152-1162. PMID: 28703881
3. Zhang, X. et al. (2017) PloS one 12, e0181653. PMID: 28738062
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-RUNX2 Polyclonal Antibody

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