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| カタログ番号 | HB172014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-S100A1 Polyclonal Antibody (HB172014) is a rabbit polyclonal antibody detecting S100A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pongo abelii.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human S100A1 (Met1-Ser94). | ||||||||
| ターゲット | S100A1, Protein S100-A1, S-100 protein alpha chain, S100 calcium-binding protein A1, S100A, S-100 protein subunit alpha | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P23297 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein S100-A1 (S100A1) is a ~10 kDa protein. Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. 1. Kiewitz, R. et al. (2003) Biochemical and biophysical research communications 306, 550-7. PMID: 12804600 2. Nowakowski, M. et al. (2013) Biochemistry 52, 1149-59. PMID: 23351007 3. Yamaguchi, F. et al. (2012) The Journal of biological chemistry 287, 13787-98. PMID: 22399290 4. Most, P. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 13889-94. PMID: 11717446 | ||||||||
| 注意事項 | For research use only. |
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