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| カタログ番号 | HX203014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-S100A12 Polyclonal Antibody (HX203014) is a rabbit polyclonal antibody detecting S100A12 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human S100A12 (Met1-Glu92). | ||||||||
| ターゲット | Migration inhibitory factor-related protein 6, MRP-6, Extracellular newly identified RAGE-binding protein, p6, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, Protein S100-A12, CGRP, S100 calcium-binding protein A12, Neutrophil S100 protein, CAAF1, EN-RAGE, S100A12, CAGC | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P80511 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein S100-A12 (S100A12) is a ~10 kDa protein. S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-S100A12 polyclonal antibody at 1μg/ml on various samples.
Lane 1: Human blood lysate
Lane 2: Human blood lysate
Lane 3: Mouse lung lysate
Lane 4: Mouse liver lysate
Lane 5: Mouse spleen lysate
Lane 6: Rat lung lysate
Lane 7: Rat liver lysate
Lane 8: Rat spleen lysate
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