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| カタログ番号 | HB419014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SAFB Polyclonal Antibody (HB419014) is a rabbit polyclonal antibody detecting Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein; SAFB; HAP; HET; SAFB1 in ELISA, IHC, WB. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SAFB (Gly405-Lys483). | ||||||||
| ターゲット | Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein; SAFB; HAP; HET; SAFB1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15424, O88453, D3YXK2, Q14151, Q80YR5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Scaffold attachment factor B1 (SAFB) is a ~102 kDa protein. Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Thereby acts as a negative regulator of cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. 1. Nayler, O. et al. (1998) Nucleic acids research 26, 3542-9. PMID: 9671816 2. Townson, SM. et al. (2003) The Journal of biological chemistry 278, 20059-68. PMID: 12660241 | ||||||||
| 注意事項 | For research use only |
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