Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1) (ZA079013)

Name: Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Antibody (4C1)
Brand: abinScience
SKU: ZA079013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

ZA079013

Reactividad de especies

Androctonus australis (Sahara scorpion)

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a

ID de clon

4C1

Objetivo

Alpha-mammal toxin AaH2, AaHII, Neurotoxin 2, Neurotoxin II

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P01484

RRID

Anti-Sahara scorpion AaH II/Neurotoxin II Antibody (4C1) (abinScience Cat# ZA079013, RRID:AB_3728994)
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Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Alpha-mammal toxin AaH2 (AaH II/Neurotoxin II) is a ~9 kDa protein. Alpha toxin that binds voltage-independently at site-3 of sodium channels (Nav), inhibits the inactivation of the activated channels, and weakly inhibits activation, thereby blocking neuronal transmission. Inserts into voltage-sensing domain IV to stabilize a deactivated state, thereby preventing fast-inactivation. Principally slows the inactivation process of TTX-sensitive sodium channels. It is active on mammalian brain Nav1.2/SCN2A (EC(50)human=0.72 nM, EC(50)rat=2.6 nM), on rat skeletal muscle Nav1.4/SCN4A (EC(50)=2.2 nM), and on human neuronal Nav1.7/SCN9A (EC(50)=6.8-51.7 nM). In vivo, intraplantar injection into mice induces spontaneous pain responses.

1. Clairfeuille, T. et al. (2019) Science (New York, N.Y.) 363. PMID: 30733386

2. Abbas, N. et al. (2013) Pain 154, 1204-15. PMID: 23685008

3. Alami, M. et al. (2003) The Biochemical journal 375, 551-60. PMID: 12911331

Nota

For research use only.

Imágenes