Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Nanobody (SAA2041) (ZA079043)

Name: Anti-Sahara scorpion AaH II/Neurotoxin II Recombinant Nanobody (SAA2041)
Brand: abinScience
SKU: ZA079043
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

ZA079043

Description

Anti-Sahara scorpion AaH II/Neurotoxin II Nanobody (SAA2041) [SAA2041] (ZA079043) is a alpaca monoclonal antibody detecting Neurotoxin II in ELISA, SPR.

Reactivité des espèces

Androctonus australis (Sahara scorpion)

Applications

ELISA, SPR

Espèce hôte

Alpaca

Clonalité

Monoclonal

Isotype

VHH-8His-Cys-tag

ID de clone

SAA2041

Cible

Alpha-mammal toxin AaH2, AaHII, Neurotoxin 2, Neurotoxin II

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Numéro d'accès

P01484

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Alpha-mammal toxin AaH2 (AaH II/Neurotoxin II) is a ~9 kDa protein. Alpha toxin that binds voltage-independently at site-3 of sodium channels (Nav), inhibits the inactivation of the activated channels, and weakly inhibits activation, thereby blocking neuronal transmission. Inserts into voltage-sensing domain IV to stabilize a deactivated state, thereby preventing fast-inactivation. Principally slows the inactivation process of TTX-sensitive sodium channels. It is active on mammalian brain Nav1.2/SCN2A (EC(50)human=0.72 nM, EC(50)rat=2.6 nM), on rat skeletal muscle Nav1.4/SCN4A (EC(50)=2.2 nM), and on human neuronal Nav1.7/SCN9A (EC(50)=6.8-51.7 nM). In vivo, intraplantar injection into mice induces spontaneous pain responses.

1. Clairfeuille, T. et al. (2019) Science (New York, N.Y.) 363. PMID: 30733386

2. Abbas, N. et al. (2013) Pain 154, 1204-15. PMID: 23685008

3. Alami, M. et al. (2003) The Biochemical journal 375, 551-60. PMID: 12911331

Note

For research use only.

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